Previous Section Next Section Nomenclature and Basic Biochemistry Common adverse effects of chelating agents include abdominal cramps, drowsiness, dizziness, rash, While chelation increases mercury excretion, the benefits of doing so have not been established In the patient and not in the laboratory values, and (c) chelation treatment is most appropriate for patients who show significant This discussion is intended primarily for pathologists and clinical chemists who are asked to interpret mercury values generatedĪlthough the treatment of mercury poisoning is not reviewed here, several points are worth summarizing: (a) the most importantĪspects of treatment are supportive care and the prevention of further exposure, (b) the object of treatment is improvement Mercury levels in other body fluids, feces, tissues, hair, and nails are not addressed. Levels in blood and urine of individuals. That influence mercury toxicity, review a portion of the literature, and provide a framework for interpretation of mercury The goals of this paper are to describe the main factors Conflicting information about mercury toxicity is also common. Not do, and because the toxic responses are often markedly different among individuals. Mercury is a problem because it has the potential to be toxic in different forms, because it is blamed for things it does Previous Section Next Section Introduction Interpretation can be aided by biological markers (eg, urine porphyrins, β2-microglobulin, and N-acetyl-β-D-glucosaminidase). Interpretation is relatively straightforward when the results are massivelyĮlevated, but becomes increasingly difficult as concentrations approach the population norms (blood and urine mercury < 10–20 The ranges reported in the literature are broad, with elevations as highĪs 16,000 μg/L in blood and 11,000 μg/L in urine. Is facilitated by comparison to published reports. Interpretation is influenced by the patient’s symptoms and When blood and urine are collected to evaluate exposure, the results are influenced by (a) specimenĬollection, (b) analysis, and (c) the time elapsed from exposure. Patient factors include age, genetics, environmental aspects, and nutritional status, and are responsible for different individual The effects of mercury exposure are determined by: (a) chemical form, (b) route of exposure, (c) dose, and (d) patient factors.
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